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Clinical Genetic Counseling Program
To refer a patient for cancer genetics evaluation, call 859-323-8718
For clinical questions, contact Dr. Pierce via UK-MDs at 1-800-888-5533 |
A key component of Markey Cancer Center's mission to provide advanced patient care and leading-edge research is the Genetic Counseling Program. The program provides risk assessment for individuals with a strong family history of cancer. Individuals who are predisposed to cancer can review clinical management options for themselves and potentially at-risk family members.
Heather Pierce, PhD, MS, brings years of experience to the Genetic Counseling Program. Dr. Pierce provides a personalized assessment of hereditary cancer risks and discusses cancer detection and risk reduction options. Patients' concerns are addressed with sensitivity and support. Genetic testing is offered when appropriate and the patient is returned to the referring physician for any necessary follow-up care.
Please read the information below about referral guidelines for cancer genetics evaluation. You can also download a copy of the referral guidelines here (PDF).
Referral Guidelines for Cancer Genetics Evaluation
Hereditary Breast-Ovarian Cancer Syndrome
Patient or first-degree relative with ANY of the following:
- Breast or ovarian cancer and two or more first- or second-degree relatives (related through a single lineage) with breast or ovarian cancer OR
- Breast or ovarian cancer and one or more relatives with breast cancer diagnosed at an early age (<50y) or ovarian cancer diagnosed at any age OR
- Breast or ovarian cancer diagnosed at an early age (<50y) OR
- Male breast cancer at any age OR
- Documented mutations in the BRCA1 or BRCA2 gene OR
- Ashkenazi Jewish descent with breast or ovarian cancer OR
- Suspicion of a genetic disorder/syndrome associated with increased risk of breast cancer
Hereditary Non-Polyposis Colorectal Cancer Syndrome (HNPCC)
Patient or first-degree relative with ANY of the following:
- 2 or more HNPCC-associated cancers (colorectum, endometrium, small bowel, ureter, renal pelvis) in the same individual OR
- Colorectal cancer with a first-degree relative with an HNPCC-associated cancer or colorectal adenoma; one of the cancers diagnosed at <50y, adenoma diagnosed at <40y OR
- Colorectal or endometrial cancer diagnosed at <45y OR
- Right-sided colon cancer with an undifferentiated pattern diagnosed <50y OR
- Signet ring cell type colorectal cancer diagnosed at <50y OR
- Adenomas diagnosed at <40y
- Documented mutation in an HNPCC-associated gene (MLH1, MSH2, MSH6)
Familial Adenomatous Polyposis (FAP)
- Patient with greater than 20 adenomatous colorectal polyps OR
- Patient or family member with a clinical diagnosis of FAP OR
- Patient or family member with a documented mutation in the APC or MYH gene
Suspicion of a genetic condition associated with increased risk of malignancy:
- Personal history of cancer, and one or more relatives with the same type of cancer, one of the cancers diagnosed <50y
- Personal history of 2 or more primary cancers, particularly if one of the diagnoses occurred <50y, and/or family history of cancer
- Family history of cancer suggestive of a known syndrome (eg breast/thyroid:Cowden, breast/sarcoma:Li-Fraumeni)
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